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    Curr Opin Struct Biol. 1997 Dec;7(6):786-92.

    GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins.

    Source

    Max-Planck-Institut für medizinische Forschung, Abteilung Biophysik, Heidelberg, Germany. geyer@mpimf-heidelberg.mpg.de

    Abstract

    Cell biology depends on the interactions of macromolecules, such as protein-DNA, protein-protein or protein-nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated.

    PMID:
    9434896
    [PubMed - indexed for MEDLINE]

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