Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Biol. 1998 Jan 15;8(2):R49-51.

DNA repair: PARP - another guardian angel?

Author information

  • 1MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK. p.a.jeggo@sussex.ac.uk

Abstract

Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.

PMID:
9427640
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk