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Ment Retard. 1997 Dec;35(6):468-72.

Effects of switching from Depakene to generic valproic acid on individuals with mental retardation.

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  • 1Abilene State School, Texas Department of Mental Health and Mental Retardation 79604, USA.


In an 8-week open-trial substitution study, 64 subjects with seizure disorders living at an ICF/MR were randomly assigned to either brand-named Depakene or generic Valproic Acid USP (Solvay) medication. After 4 weeks, they were switched to the other medication. Blood levels and seizures were monitored. The price of the generic Valproic Acid was less than one tenth the price of Depakene. Results show that subjects had no statistically significant changes in seizures or blood levels when the two treatment regimens were compared. These findings suggest that generic Valproic Acid USP (Solvay) may be successfully used in this population, resulting in substantial cost savings.

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