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Curr Opin Cell Biol. 1997 Dec;9(6):800-6.

The metaphase-to-anaphase transition: avoiding a mid-life crisis.

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  • 1Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, MD 21210, USA.


The metaphase-to-anaphase transition is a highly regulated process, which is governed by the activity of the anaphase-promoting complex (APC). The APC promotes the degradation of several proteins, including mitotic cyclins and newly identified anaphase inhibitors. Several discoveries made this year shed invaluable light on the regulation of APC activation and its substrate specificity.

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