Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Department of Medical Genetics, Beijer Laboratory, University of Uppsala, Sweden.
Analyses of the coding sequences of HLA class II alleles have revealed high similarity between species, indicating that much of the polymorphism predates the separation of human (Homo) and chimpanzee (Pan), 4-7.4 million years ago. Recent studies of the intron sequences of alleles provide support for a much more recent origin and rapid generation of HLA alleles. At the DRB1 locus, intron analysis indicates that most of the allelic lineages have diverged from each other before the separation of Homo and Pan, consistent with the exon analysis. However, the intron sequences of alleles within lineages are almost identical, indicating that many of the alleles have been generated after the divergence of the Homo and Pan lineages.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on