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J Virol. 1998 Jan;72(1):415-9.

The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses.

Author information

  • 1Division of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. bergelson@email.chop.edu

Abstract

Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated. Nonpermissive CHO cells transfected with mCAR cDNA became susceptible to infection by coxsackieviruses B3 and B4 and showed increased susceptibility to adenovirus-mediated gene transfer. These results indicate that the same receptor is responsible for virus interactions with both murine and human cells. Analysis of receptor expression in human and murine tissues should be useful in defining factors governing virus tropism in vivo.

PMID:
9420240
[PubMed - indexed for MEDLINE]
PMCID:
PMC109389
Free PMC Article

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