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Vaccine. 1997 Dec;15(17-18):1959-62.

Aqueous-based microcapsules are detected primarily in gut-associated dendritic cells after oral inoculation of mice.

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  • 1Section of Infectious Diseases, Children's Hospital of Philadelphia, PA, USA.


We previously found that aqueous-based microencapsulation enhanced virus-specific humoral immune responses after oral inoculation of mice. However, the mechanism by which microencapsulation enhances immunogenicity remains unclear. We found that spermine-alginate microcapsules were detected primarily in gut-associated dendritic cells (i.e. CD11c/CD18+, Ia+, CD11b-, CD45R-) after oral inoculation of adult mice. Microencapsulation may enhance immunogenicity by involving antigen presenting cells which are more efficient than those recruited during natural infection.

[PubMed - indexed for MEDLINE]
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