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J Clin Gastroenterol. 1997 Oct;25(3):538-40.

Nonalcoholic steatohepatitis masquerading as autoimmune hepatitis.

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  • 1Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Japan.


Nonalcoholic steatohepatitis is an increasingly recognized clinicopathologic condition. We report two cases of nonalcoholic steatohepatitis in middle-aged Japanese women whose clinical and laboratory data mimicked autoimmune hepatitis. Histologic findings of both cases were definite steatohepatitis with portal and pericellular fibrosis. Both patients' HLA-DR haplotypes were DR4 and DR2, which are frequently observed in Japanese patients with autoimmune hepatitis. Our cases suggest a diversity in the pathogenesis of nonalcoholic steatohepatitis.

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