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Pathologica. 1997 Apr;89(2):184-8.

[Malignant paraganglioma of the posterior mediastinum with 27 years follow-up].

[Article in Italian]

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  • 1Dipartimento Clinico di Scienze Radiologiche e Istocitopatologiche, Universit√† di Bologna.



A costovertebral paraganglioma with a long history of recurrences and metastases is reported.


The lesion is documented on histological ground and with immunocytochemistry and electron microscopy.


The patient is a 42 year old man which presented with a 5 cm axillary mass and enlarged mediastinal lymph nodes. The former lesion has been interpreted as a metastasis of paraganglioma. The patient underwent surgery because of a costovertebral paraganglioma at the age of 19 and showed locoregional metastases and a recurrence over a period of 23 years. Twenty-seven years from removal of the primitive tumor, the patient is alive and well. All the neoplasms showed identical histological features as they were composed of neoplastic elements arranged in nests surrounded by dendritic cells. Neoplastic cells immunoreacted with anti-chromogranin antiserum whereas sustentacolar cells were positive with S-100 antiserum.


The differential diagnosis between a multicentric paraganglioma a metastasis has been particularly taken into consideration. In addition, axillary tumor was distinguished from a metastatic renal cell carcinoma and melanoma. The literature regarding costovertebral paraganglioma has been also revised.

[PubMed - indexed for MEDLINE]
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