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Science. 1997 Dec 19;278(5346):2117-20.

Natural variation in a Drosophila clock gene and temperature compensation.

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  • 1Department of Genetics, University of Leicester, LE1 7RH, UK.

Abstract

The threonine-glycine (Thr-Gly) encoding repeat within the clock gene period of Drosophila melanogaster is polymorphic in length. The two major variants (Thr-Gly)17 and (Thr-Gly)20 are distributed as a highly significant latitudinal cline in Europe and North Africa. Thr-Gly length variation from both wild-caught and transgenic individuals is related to the flies' ability to maintain a circadian period at different temperatures. This phenomenon provides a selective explanation for the geographical distribution of Thr-Gly lengths and gives a rare glimpse of the interplay between molecular polymorphism, behavior, population biology, and natural selection.

PMID:
9405346
[PubMed - indexed for MEDLINE]
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