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Leuk Lymphoma. 1997 Oct;27(3-4):247-56.

Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells.

Author information

  • 1Division of Experimental Medicine, Harvard Institutes of Medicine-BIDMC, Boston, MA 02115, USA.

Abstract

Protein tyrosine kinases (PTKs) mediate signals that respond to many pivotal cellular functions. Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and PTKs, is a critical control mechanism for various physiological processes, including cell growth, differentiation, metabolism, cell cycle regulation and cytoskeleton function. The focal adhesion kinase (FAK) is a widely expressed non-receptor tyrosine kinase that is implicated in integrin-mediated signaling and plays a role in signal transduction pathways mediating cell adhesion, motility and anchorage-independent growth. Recently, we and others have identified a novel protein tyrosine kinase termed RAFTK, (also known as Pyk2 or Cak-beta), which is related to FAK. This review describes the role of RAFTK in various signaling cascades mainly in reference to hematopoietic cell lineages.

PMID:
9402324
[PubMed - indexed for MEDLINE]
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