An exonic polymorphism in the human glucose phosphate isomerase (GPI) gene

Blood Cells Mol Dis. 1997 Dec;23(3):377-9. doi: 10.1006/bcmd.1997.0154.

Abstract

A polymorphic site has been found in the human glucose phosphate isomerase (GPI) gene. This site is produced by a A-->G substitution at nt 489 of GPI cDNA, resulting in a silent mutation. To our knowledge, it is the first defined polymorphism in the gene. It is present with similar gene frequencies in Asian, American White, African American, and Jewish populations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Asian People / genetics
  • Black People / genetics
  • Exons*
  • Gene Frequency
  • Glucose-6-Phosphate Isomerase / genetics*
  • Humans
  • Jews / genetics
  • Point Mutation
  • Polymorphism, Genetic / genetics*
  • White People / genetics

Substances

  • Glucose-6-Phosphate Isomerase