Arch Dermatol. 1997 Oct;133(10):1280-4.

Photoaging and topical tretinoin: therapy, pathogenesis, and prevention.

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Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109, USA.

Erratum in

Arch Dermatol 1998 Jan;134(1):38.

Abstract

Repeated exposure to UV radiation from the sun causes premature skin aging. This photoaging is characterized by wrinkles, mottled pigmentations, dry and rough skin, and loss of skin tone. Since the clinical demonstration that the use of topical tretinoin can improve photoaged skin, a great deal of knowledge that may explain wrinkle effacement has been acquired. Central to this pursuit has been dermal collagen. In this article, we summarize evidence (mainly from humans) that implicates a deficiency of superficial dermal collagen as the cause of the dermal aspects of photoaging. In addition, a mechanism through which UV radiation can lead to reduced collagen is presented. Through our understanding of the pathophysiological mechanism of photoaging, our ability to treat and possibly prevent this skin condition is enhanced.

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Review Photoaging: pathogenesis, prevention, and treatment. [Clin Geriatr Med. 2001]
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Cited by 2 PubMed Central articles

How much do we really know about our favorite cosmeceutical ingredients? [J Clin Aesthet Dermatol. 2010]
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Fu JJ, Hillebrand GG, Raleigh P, Li J, Marmor MJ, Bertucci V, Grimes PE, Mandy SH, Perez MI, Weinkle SH, et al. Br J Dermatol. 2010 Mar; 162(3):647-54.

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