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1: Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11013-8.Click here to read Click here to read Links

hSK4, a member of a novel subfamily of calcium-activated potassium channels.

Joiner WJ, Wang LY, Tang MD, Kaczmarek LK.

Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

The gene for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells. In physiological saline hSK4 generates a conductance of approximately 12 pS, a value in close agreement with that of other cloned SK channels. Like other members of this family, the polypeptide encoded by hSK4 contains a previously unnoted leucine zipper-like domain in its C terminus of unknown function. hSK4 appears unique, however, in its very high affinity for Ca2+ (EC50 of 95 nM) and its predominant expression in nonexcitable tissues of adult animals. Together with the relatively low homology of hSK4 to other SK channel polypeptides (approximately 40% identical), these data suggest that hSK4 belongs to a novel subfamily of SK channels.

PMID: 9380751 [PubMed - indexed for MEDLINE]

PMCID: PMC23566

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