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    Science. 1997 Nov 28;278(5343):1612-5.

    IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

    Muzio M, Ni J, Feng P, Dixit VM.

    Source

    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA.

    Abstract

    The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.

    PMID:
    9374458
    [PubMed - indexed for MEDLINE]

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