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J Reprod Immunol. 1997 Nov 1;35(1):43-51.

Evidence for a long-lasting single administration contraceptive vaccine in wild grey seals.

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  • 1Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada. rbrow437@is.dal.ca

Abstract

A single-administration birth control vaccine based on liposome delivery of porcine zona pellucida antigens reduced pup production in grey seals (Halichoerus grypus) by about 90%. Anti-porcine zona pellucida titers of individual seals with two or more recaptures were variable but without a diminishing trend during the 5 year post-immunization period. Seals that produced at least one or more pups during the 2-5 year post-immunization period when the vaccine is fully effective, had an average anti-porcine zona pellucida titer of 5% of the reference serum. In contrast, the subset of seals that did not reproduce but were recaptured during the breeding season had an average titer of 31% of the reference serum. As measured by antibody titers and pup production, there were no differences in efficacy of the vaccine in 14-, 20- and 21-year-old female grey seals.

PMID:
9373857
[PubMed - indexed for MEDLINE]
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