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    FASEB J. 1997 Nov;11(13):1067-75.

    Cell cycle regulation by the ubiquitin pathway.

    Pagano M.

    Source

    Department of Pathology and Kaplan Cancer Center, New York University Medical Center, New York 10016, USA.

    Abstract

    In the past 2 years, two ubiquitin-dependent proteolytic pathways have been established as important players in the regulation of the cell division cycle. In S. cerevisiae, the entry into S phase requires ubiquitin-mediated degradation of a cdk inhibitor, p40Sic1, in a pathway that involves the E2 enzyme Cdc34. Recent studies reviewed herein show that the Cdc34 pathway targets phosphorylated substrates. A second pathway that regulates chromosome segregation and mitotic exit by degrading anaphase inhibitors and mitotic cyclins involves a different E2 and a large molecular weight E3 complex, called the anaphase-promoting complex or cyclosome. This pathway targets substrates containing one or more destruction box motif.

    PMID:
    9367342
    [PubMed - indexed for MEDLINE]
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