In this report, mortality with influenza in Japan was analyzed. The data covered mainly the period 1975-94. I tried to analyze these data for cause of death, viral types, age groups and three categories of diseases in order to determine distinctive risk factors for influenza-associated mortality. To summarize, influenza is a common disease which could lead especially for the elderly and those who have increased risk factors (cardiovascular diseases, cerebrovascular diseases and pulmonary complications) to severe complications and death. The cause of death is thought to be mainly influenza related pneumonia. Elderly and high-risk persons should be vaccinated.