Trends Biochem Sci. 1997 Oct;22(10):388-93.

Caspases and caspase inhibitors.

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Institute of Cell and Molecular Biology, University of Edinburgh, UK.

Abstract

Five years ago, little was known about mechanisms of apoptotic execution. Now, one class of cell-death gene, the cysteine and aspartases (caspases) has come under intensive study. This review discusses the two classes of caspases, the reasons why humans may have so many caspase genes, the growing list of caspase substrates, and viral and pharmacological caspase inhibitors.

PMID:: 9357314; [PubMed - indexed for MEDLINE]

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