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Trends Biochem Sci. 1997 Oct;22(10):383-7.

The ubiquitin system.

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  • 1Division of Biology, California Institute of Technology, Pasadena 91125, USA.


Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.

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