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Immunol Today. 1997 Oct;18(10):498-504.

CD6-ligand interactions: a paradigm for SRCR domain function?

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  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA.


The scavenger receptor cysteine-rich (SRCR) superfamily, which includes proteins expressed by leukocytes, can be subdivided into groups A and B. Group B contains the lymphocyte cell-surface receptor CD6. This article reviews recent progress in understanding the interaction between CD6 and its ligand, activated leukocyte cell adhesion molecule (ALCAM). Analysis of the CD6-ALCAM interaction may help to understand how other SRCR domains bind to their ligands.

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