In vivo radiotracers for vesicular neurotransmitte...[Nucl Med Biol. 1997]

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1: Nucl Med Biol. 1997 Oct;24(7):615-9. Links

In vivo radiotracers for vesicular neurotransmitter transporters.

Kilbourn MR.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109, USA.

The vesicular monoamine transporter is a specific presynaptic protein involved in the transport of monoamines from the cytosol to storage vesicles of monoaminergic nerve terminals. Recently, radioligands for this transporter have been developed and utilized for in vivo positron emission tomographic (PET) imaging of monoaminergic nerve terminals in the human brain. In this review, the characteristics of vesicular transport and storage that provided the impetus for development of these radioligands are presented and discussed.

PMID: 9352531 [PubMed - indexed for MEDLINE]

ReviewVesicular neurotransmitter transporters. Potential sites for the regulation of synaptic function.
Mol Neurobiol. 1997 Oct; 15(2):165-91.

[Mol Neurobiol. 1997]
ReviewVesicular neurotransmitter transport and the presynaptic regulation of quantal size.
Curr Opin Neurobiol. 1998 Jun; 8(3):405-12.

[Curr Opin Neurobiol. 1998]
ReviewRegulation of vesicular neurotransmitter transporters.
Rev Physiol Biochem Pharmacol. 2003; 150:140-60. Epub 2003 Sep 27.

[Rev Physiol Biochem Pharmacol. 2003]
ReviewIn vivo imaging of the vesicular acetylcholine transporter and the vesicular monoamine transporter.
FASEB J. 2000 Dec; 14(15):2401-13.

[FASEB J. 2000]
The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons.
J Neurosci. 1998 Dec 1; 18(23):9733-50.

[J Neurosci. 1998]
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Cited by 3 PubMed Central articles

Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters.
Kung MP, Hou C, Goswami R, Ponde DE, Kilbourn MR, Kung HF. Nucl Med Biol. 2007 Apr; 34(3):239-46.

[Nucl Med Biol. 2007]
Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain.
Kilbourn MR, Hockley B, Lee L, Hou C, Goswami R, Ponde DE, Kung MP, Kung HF. Nucl Med Biol. 2007 Apr; 34(3):233-7.

[Nucl Med Biol. 2007]
Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.
Souza F, Simpson N, Raffo A, Saxena C, Maffei A, Hardy M, Kilbourn M, Goland R, Leibel R, Mann JJ, et al. J Clin Invest. 2006 Jun; 116(6):1506-13. Epub 2006 May 18.

[J Clin Invest. 2006]

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Cited by 3 PubMed Central articles

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