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J Virol. 1997 Nov;71(11):8856-9.

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator.

Author information

  • 1Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. kato-2im@h.u-tokyo.ac.jp

Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

PMID:
9343247
[PubMed - indexed for MEDLINE]
PMCID:
PMC192353
Free PMC Article
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