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HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region.
Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B.
AIDS. 1997 Oct;11(12):1421-31.
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The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.
Barillari G, Gendelman R, Gallo RC, Ensoli B.
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