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Nature. 1997 Oct 16;389(6652):689-95.

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.

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  • 1Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. sdy1@columbia.edu

Abstract

Amyloid-beta is a neurotoxic peptide which is implicated in the pathogenesis of Alzheimer's disease. It binds an intracellular polypeptide known as ERAB, thought to be a hydroxysteroid dehydrogenase enzyme, which is expressed in normal tissues, but is overexpressed in neurons affected in Alzheimer's disease. ERAB immunoprecipitates with amyloid-beta, and when cell cultures are exposed to amyloid-beta, ERAB inside the cell is rapidly redistributed to the plasma membrane. The toxic effect of amyloid-beta on these cells is prevented by blocking ERAB and is enhanced by overexpression of ERAB. By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease.

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PMID:
9338779
[PubMed - indexed for MEDLINE]
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