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Br J Psychiatry. 1997 Sep;171:280-2.

Brain 5-HT function in obsessive-compulsive disorder. Prolactin responses to d-fenfluramine.

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  • 1St Mary's Hospital, London.

Abstract

BACKGROUND:

Drugs that potentiate brain serotonin (5-HT) neurotransmission are effective in the treatment of obsessive-compulsive disorder (OCD), but it is unclear whether disturbances in brain 5-HT function play a role in the pathophysiology of OCD.

METHOD:

We studied the prolactin response to the selective 5-HT releasing agent d-fenfluramine in 14 non-depressed, drug-free OCD patients, and 14 healthy controls matched for age and gender.

RESULTS:

The prolactin response to d-fenfluramine was significantly increased in OCD patients compared with controls.

CONCLUSIONS:

The disparate results of studies of 5-HT neuroendocrine function in OCD make it unlikely that disturbances of brain 5-HT function play a central role in the pathophysiology of OCD. Increased brain 5-HT neurotransmission in non-depressed OCD subjects may represent an adaptive neurobehavioural mechanism which can be amplified to therapeutic advantage by treatment with 5-HT potentiating drugs.

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PMID:
9337985
[PubMed - indexed for MEDLINE]
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