Format

Send to

Choose Destination
See comment in PubMed Commons below
Biosci Rep. 1997 Jun;17(3):293-302.

Redox regulation of the mitochondrial permeability transition pore.

Author information

  • 1A. N. Belozersky Institute of Physio-Chemical Biology, Moscow State University, Russia.

Abstract

The recent data on redox regulation of the mitochondrial cyclosporin-sensitive pore are reviewed here. They indicate that the pore is modulated by the redox state of pyridine nucleotides and glutathione at two independent sites. Special attention is paid to experimental approaches for studying this phenomenon in isolated mitochondria. The relation between oxidative stress and the opening of the mitochondrial pore in some cases of cell injury and in programmed cell death (apoptosis) is discussed.

PMID:
9337484
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk