Pharmacol Ther. 1997;74(2):195-205.

DNA vaccines.

Montgomery DL, Ulmer JB, Donnelly JJ, Liu MA.

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Department of Virus and Cell Biology, Merck Research Laboratories, West Point, PA 19486, USA.

Abstract

In just a few years, injection of plasmid DNA to elicit immune responses in vivo has developed from an interesting observation to a viable vaccine strategy. DNA vaccines have been shown to elicit both cellular and humoral immune responses and to be effective in a variety of preclinical bacterial, viral, and parasitic animal models. This review will discuss the current knowledge of vector design, methods of plasmid delivery, immune responses elicited by various DNA vaccines, safety issues, and production and release of plasmid as a vaccine product. The potential of this new vaccine strategy and its future prospects is summarized.

PMID:: 9336022; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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Review

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Vaccines, DNA

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Cited by 12 PubMed Central articles

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Chen R, Lu SH, Tong QB, Lou D, Shi DY, Jia BB, Huang GP, Wang JF. J Zhejiang Univ Sci B. 2009 Jul; 10(7):512-21.
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