JACEP. 1976 Jun;5(6):443-5.

Physostigmine in tricyclic antidepressant overdose.

Abstract

Acute accidental and suicidal overdosages are becoming common in emergency medicine. Physostigmine salicylate (Antilirium) is the only parasympathomimetic drug capable of reversing both the central and peripheral manifestations of the anticholinergic syndrome caused by overdosage of tricyclic antidepressant drugs. Physostigmine acts rapidly, within 5 to 20 minutes, dramatically reversing the toxic effects. Because of the short duration of action, intoxication may recur and repeated doses may be necessary. Four cases, successfully managed, are presented and the pertinent literature reviewed.

PMID:: 933413; [PubMed - indexed for MEDLINE]

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Reversal of tricyclic-overdosage-induced central anticholinergic syndrome by physostigmine. [Am J Psychiatry. 1976]
Reversal of tricyclic-overdosage-induced central anticholinergic syndrome by physostigmine.
Holinger PC, Klawans HL. Am J Psychiatry. 1976 Sep; 133(9):1018-23.
Physostigmine salicylate in the treatment of tricyclic antidepressant overdosage. [JAMA. 1975]
Physostigmine salicylate in the treatment of tricyclic antidepressant overdosage.
Newton RW. JAMA. 1975 Mar 3; 231(9):941-3.
Use of physostigmine in tricyclic antidepressant poisoning. [Anaesth Intensive Care. 1976]
Use of physostigmine in tricyclic antidepressant poisoning.
Chin LS, Havill JH, Rothwell RP, Bishop BG. Anaesth Intensive Care. 1976 May; 4(2):138-40.
Review [Poisoning due to tricyclic antidepressants in children and adolescents]. [Can Med Assoc J. 1979]
Review [Poisoning due to tricyclic antidepressants in children and adolescents].
Rollin P, Antaki AJ. Can Med Assoc J. 1979 Apr 21; 120(8):951-6.
Review Poisoning due to tricyclic antidepressant overdosage. Clinical presentation and treatment. [Med Toxicol. 1986]
Review Poisoning due to tricyclic antidepressant overdosage. Clinical presentation and treatment.
Crome P. Med Toxicol. 1986 Jul-Aug; 1(4):261-85.

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