J Infect Dis. 1997 Oct;176(4):913-23.

Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necrosis factor-alpha activity in human immunodeficiency virus type 1 infection.

Aukrust P, Hestdal K, Lien E, Bjerkeli V, Nordøy I, Espevik T, Müller F, Frøland SS.

Source

Medical Department A and Research Institute for Internal Medicine, University of Oslo, National Hospital, Rikshospitalet, Norway.

Abstract

The effect of a single bolus injection (0.4 g/kg) of intravenous immunoglobulin (IVIG) on the tumor necrosis factor (TNF) system in human immunodeficiency virus type 1 (HIV-1)-infected patients was investigated. At 140 h after infusion, there was a significant decrease in levels of TNF-alpha and a significant increase in levels of soluble TNF receptors (sTNFR) in both plasma and lipopolysaccharide-stimulated peripheral blood mononuclear cells (PBMC). A rapid (within 1 h) decline in expression of membrane-bound TNF-alpha and p55-TNFR on PBMC persisted throughout the study. In contrast, there was an increased expression of membrane-bound p75-TNFR after 140 h. IVIG administration also resulted in significantly increased numbers of circulating CD4 lymphocytes, correlated with down-regulation of TNF-alpha activity in PBMC supernatants. Thus, down-regulation of the abnormally increased TNF-alpha activity may be achieved by IVIG administration. Studies evaluating the possible therapeutic role of long-term TNF-alpha suppression by IVIG may be warranted in HIV-1-infected patients.

PMID:: 9333149; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Dysregulation of membrane-bound tumor necrosis factor-alpha and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1 infection: low percentage of p75-tumor necrosis factor receptor positive cells in patients with advanced disease and high viral load. [Blood. 1997]
Dysregulation of membrane-bound tumor necrosis factor-alpha and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1 infection: low percentage of p75-tumor necrosis factor receptor positive cells in patients with advanced disease and high viral load.
Hestdal K, Aukrust P, Müller F, Lien E, Bjerkeli V, Espevik T, Frøland SS. Blood. 1997 Oct 1; 90(7):2670-9.
Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure. [J Infect Dis. 1999]
Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure.
Aukrust P, Müller F, Lien E, Nordoy I, Liabakk NB, Kvale D, Espevik T, Froland SS. J Infect Dis. 1999 Jan; 179(1):74-82.
Tumor necrosis factor alpha and soluble tumor necrosis factor receptors in individuals with human immunodeficiency virus infection. [Immunol Lett. 1994]
Tumor necrosis factor alpha and soluble tumor necrosis factor receptors in individuals with human immunodeficiency virus infection.
Zangerle R, Gallati H, Sarcletti M, Wachter H, Fuchs D. Immunol Lett. 1994 Jul; 41(2-3):229-34.
Review Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis? [AIDS Rev. 2006]
Review Are blockers of gp120/CD4 interaction effective inhibitors of HIV-1 immunopathogenesis?
Herbeuval JP, Shearer GM. AIDS Rev. 2006 Jan-Mar; 8(1):3-8.
Review Is HIV infection a TNF receptor signalling-driven disease? [Trends Immunol. 2008]
Review Is HIV infection a TNF receptor signalling-driven disease?
Herbein G, Khan KA. Trends Immunol. 2008 Feb; 29(2):61-7.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Immunomodulatory action of intravenous immunoglobulin. [Immunology. 2002]
Review Immunomodulatory action of intravenous immunoglobulin.
Sewell WA, Jolles S. Immunology. 2002 Dec; 107(4):387-93.
In vivo modulation of cytokine synthesis by intravenous immunoglobulin. [Clin Exp Immunol. 1999]
In vivo modulation of cytokine synthesis by intravenous immunoglobulin.
Sewell WA, North ME, Cambronero R, Webster AD, Farrant J. Clin Exp Immunol. 1999 Jun; 116(3):509-15.
Administration of intravenous immunoglobulin (IVIG) in vivo--down-regulatory effects on the IL-1 system. [Clin Exp Immunol. 1999]
Administration of intravenous immunoglobulin (IVIG) in vivo--down-regulatory effects on the IL-1 system.
Aukrust P, Müller F, Svenson M, Nordøy I, Bendtzen K, Frøland SS. Clin Exp Immunol. 1999 Jan; 115(1):136-43.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necr...
Effects of intravenous immunoglobulin in vivo on abnormally increased tumor necrosis factor-alpha activity in human immunodeficiency virus type 1 infection.
J Infect Dis. 1997 Oct ;176(4):913-23.

PubMed
Predictors of disease progression in HIV-infected homosexual men with CD4+ cells...
Predictors of disease progression in HIV-infected homosexual men with CD4+ cells < 200 x 10(6)/l but free of AIDS-defining clinical disease.
AIDS. 1994 Nov ;8(11):1577-83.

PubMed
A human T cell-specific molecule is a member of a new gene family.
A human T cell-specific molecule is a member of a new gene family.
J Immunol. 1988 Aug 1 ;141(3):1018-25.

PubMed
Use of neem oil as a mosquito repellent in tribal villages of mandla district, m...
Use of neem oil as a mosquito repellent in tribal villages of mandla district, madhya pradesh.
Indian J Malariol. 1995 Sep ;32(3):99-103.

PubMed
Variations in HIV prevalence between urban areas in sub-Saharan Africa: do we un...
Variations in HIV prevalence between urban areas in sub-Saharan Africa: do we understand them?
AIDS. 1995 ;9 Suppl A:S103-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: