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BMJ. 1997 Aug 30;315(7107):505-10.

Randomised, double blind, placebo controlled clinical trial of efficacy of vitamin A treatment in non-measles childhood pneumonia.

Author information

  • 1Universidade Federal de Pernambuco, Cidade Universitária, Recife-PE, Brazil.

Abstract

OBJECTIVE:

To evaluate the impact on clinical recovery and severity of the addition of large doses of vitamin A to the standard treatment for childhood pneumonia.

DESIGN:

A randomised, double blind, placebo controlled trial.

SETTING:

Study children were recruited at a public hospital in Recife, north east Brazil, an area of marginal vitamin A deficiency.

SUBJECTS:

472 children aged 6 to 59 months with clinical diagnosis of pneumonia.

INTERVENTIONS:

200,000 IU (infants) or 400,000 IU (1-4 year olds) of vitamin A in oil or similar capsules of placebo divided into two daily oral doses, in addition to the standard treatment.

MAIN OUTCOME MEASURES:

Duration of the episode and incidence of adverse outcomes.

RESULTS:

The groups were similar with respect to overall duration of pneumonia and incidence of adverse outcomes. Children who received vitamin A, however, were less likely to have fever by day 3 (P = 0.008) and were 29% less likely to fail to respond to the first line antibiotic (P = 0.054).

CONCLUSION:

There was little evidence for an effect of vitamin A treatment on the immediate outcome of the pneumonia episode.

PMID:
9329303
[PubMed - indexed for MEDLINE]
PMCID:
PMC2127384
Free PMC Article
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