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    Br J Cancer. 1997;76(7):852-4.

    Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy.

    Kelsey KT, Ross D, Traver RD, Christiani DC, Zuo ZF, Spitz MR, Wang M, Xu X, Lee BK, Schwartz BS, Wiencke JK.

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    Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115, USA.

    Abstract

    The NAD(P)H quinone oxidoreductase (NQO1:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.

    PMID:
    9328142
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2228056
    Free PMC Article

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