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Eksp Klin Farmakol. 1997 May-Jun;60(3):16-9.

[Contribution of the midbrain raphe nuclei and locus ceruleus to realization of lithium hydrobutyrate rhythm modulating properties].

[Article in Russian]


Electrolytic destruction of the median raphe nuclei or locus ceruleus (I = 1.5-2.0 V, 20 sec with a change of polarity) in the period of winter solstice weakens the manifestation of free flowing rhythms of the active-search component of behavior. Lithium hydroxybutyrate (10 mg/kg i.m. for one week) only after evening administration compensates the effects of lysis of the serotonin- or norepinephrine-containing stem cells on the behavioral rhythm. Whatever the phase of administration, the drug acts as a social time-assigner for body temperature rhythms under the indicated conditions.

[PubMed - indexed for MEDLINE]
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