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1: Infect Immun. 1997 Oct;65(10):4337-40.Click here to read Click here to read Links

Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages.

Denoel PA, Crawford RM, Zygmunt MS, Tibor A, Weynants VE, Godfroid F, Hoover DL, Letesson JJ.

U. R. Biologie Moléculaire, Laboratoire de Microbiologie et d'Immunologie, Facultés Universitaires Notre Dame de la Paix, Namur, Belgium. Philippe.Denoel@fundp.ac.be

A bacterioferritin (BFR) deletion mutant of Brucella melitensis 16M was generated by gene replacement. The deletion was complemented with a broad-host-range vector carrying the wild-type bfr gene, pBBR-bfr. The survival and growth of the mutant, B. melitensis PAD 2-78, were similar to those of its parental strain in human monocyte-derived macrophages (MDM). These results suggest that BFR is not essential for the intracellular survival of B. melitensis in human MDM.

PMID: 9317046 [PubMed - indexed for MEDLINE]

PMCID: PMC175622