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Fetal Diagn Ther. 1997 May-Jun;12(3):170-7.

Effect of antenatal betamethasone and dexamethasone administration on fetal heart rate variability in growth-retarded fetuses.

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  • 1Fetal Medicine Unit, Hôpital Antoine-Beclere, Clamart, France.

Abstract

PURPOSE:

To study the effect of betamethasone and dexamethasone on fetal heart rate in 55 growth-retarded fetuses.

MATERIAL AND METHODS:

Fifty-five fetuses with intrauterine growth retardation were exposed in utero to betamethasone (group 1, n = 32) or dexamethasone (group 2; n = 17). Six fetuses received both steroids alternatively at weekly intervals. Computerized cardiotocograms were recorded and analyzed retrospectively. Traces were obtained before, 1 day, 2 days and 4-7 days after treatment was started.

RESULTS:

One day after treatment was started, both steroids were associated with an initial increase in fetal heart rate variation that was higher with dexamethasone. Short-term variation was significantly decreased during the betamethasone course. All parameters returned to their pretreatment values within a week.

CONCLUSION:

Dexamethasone and betamethasone had similar effects compatible with a transient damping effect on fetal heart rate variability that reached significance only with betamethasone.

PMID:
9313077
[PubMed - indexed for MEDLINE]
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