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J Virol. 1997 Oct;71(10):7851-6.

Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice.

Author information

  • 1Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 19104, USA. coffin@email.chop.edu

Abstract

The capacity of intramuscular (i.m.) inoculation of mice with homologous or heterologous host rotaviruses to induce protection from challenge was evaluated. i.m. inoculation with live, wild-type rotavirus (murine strain EDIM) induced complete protection from viral shedding after challenge for at least 6 weeks after inoculation; protection was correlated with production of virus-specific immunoglobulin A (IgA) by lamina propria (LP) lymphocytes. i.m. inoculation with inactivated EDIM, cell culture-adapted EDIM, or simian strain RRV was associated with partial protection, characterized by reduced viral shedding after challenge. Partial protection after challenge was not associated with production of virus-specific IgA by LP lymphocytes. The mechanisms by which i.m. inoculation induces virus-specific humoral immune responses in the small intestinal LP were examined.

PMID:
9311873
[PubMed - indexed for MEDLINE]
PMCID:
PMC192140
Free PMC Article
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