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Trends Biochem Sci. 1997 Sep;22(9):355-8.

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.

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  • 1Imperial Cancer Research Fund, London, UK.


PKB/Akt is a serine/threonine kinase that contains a pleckstrin-homology (PH) domain and is activated in response to growth-factor treatment of cells by a mechanism involving phosphoinositide 3-OH kinase. PKB/Akt provides a survival signal that protects cells from apoptosis induced by various stresses, perhaps explaining its discovery as a retroviral oncogene and its amplification in many human tumours.

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