Abstract
Insulin and growth factors elicit rapid increases in protein synthesis by stimulating mRNA translation. PHAS/4E-BPs, a recently discovered family of elF4E-binding, proteins, appear to play a key role in this process, as well as in the control of cell proliferation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Animals
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Carrier Proteins*
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Cell Cycle Proteins
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Cell Division / physiology
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Humans
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Intracellular Signaling Peptides and Proteins
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Molecular Sequence Data
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Phosphoproteins / genetics
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Phosphoproteins / physiology*
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Phosphorylation
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Protein Biosynthesis
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RNA, Messenger / genetics*
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Rats
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Signal Transduction
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Cell Cycle Proteins
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EIF4EBP1 protein, human
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Eif4ebp1 protein, rat
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Intracellular Signaling Peptides and Proteins
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Phosphoproteins
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RNA, Messenger
Associated data
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SWISSPROT/L36055
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SWISSPROT/L36056
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SWISSPROT/U05014
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SWISSPROT/U75530