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Trends Biochem Sci. 1997 Sep;22(9):326-31.

Archaeal introns: splicing, intercellular mobility and evolution.

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  • 1RNA Regulation Centre, University of Copenhagen, Denmark.


Until recently, it appeared that archaeal introns were spliced by a process specific to the archaeal domain in which an endoribonuclease cuts a 'bulge-helix-bulge' motif that forms at exon-intron junctions. Recent results, however, have shown that the endoribonuclease involved in archaeal intron splicing is a homologue of two subunits of the enzyme complex that excises eukaryotic nuclear tRNA introns. Moreover, some archaeal introns encode homing enzymes that are also encoded by group I introns.

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