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Semin Cancer Biol. 1997 Apr;8(2):63-73.

Rel/NF-kappa B and I kappa B proteins: an overview.

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  • 1Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.


Rel/NF-kappa B proteins constitute a family of structurally-related transcription factors that are regulated by interaction with a family of regulatory proteins, the I kappa B proteins. In this review, we will familiarize the reader with the known Rel/NF-kappa B and I kappa B molecules, and will discuss the types of interactions that occur between these proteins to regulate their function. In addition, we will describe what is known about the structure of Rel/NF-kappa B transcription complexes on DNA. Lastly, we will discuss the wide variety of biological stimuli and conditions which activate NF-kappa B and the genes whose expression are regulated by this family of transcription factors.

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