Send to:

Choose Destination
See comment in PubMed Commons below
Immunol Today. 1997 Sep;18(9):450-4.

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

Author information

  • 1Dept of Pathology and Laboratory Medicine, UCLA School of Medicine 90095-1732, USA.


Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk