The role of CD1 molecules in immune responses to infection

Curr Opin Immunol. 1997 Aug;9(4):456-61. doi: 10.1016/s0952-7915(97)80095-7.

Abstract

Recent work on CD1 molecules has demonstrated that human CD1b and a lipoglycan from mycobacteria that CD1b presents colocalize to late endosomes. Presentation of this lipoglycan by CD1b requires antigen uptake via the mannose receptor. CD8(+) CD1-restricted T cells can decrease the load of intracellular mycobacteria by granule release. TCR-transgenic and CD1-deficient mice have provided insights into the role of CD1 in the T helper responses required for the clearance of some microorganisms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Antigens, Bacterial / immunology
  • Antigens, CD1 / physiology*
  • Antigens, Protozoan / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Endosomes / immunology
  • Humans
  • Infections / immunology*
  • Leishmaniasis / immunology
  • Lipopolysaccharides / immunology
  • Mice
  • Mice, Transgenic
  • Mycobacterium / immunology
  • Mycobacterium Infections / immunology
  • Receptors, Antigen, T-Cell / deficiency
  • Receptors, Antigen, T-Cell / immunology

Substances

  • Antigens, Bacterial
  • Antigens, CD1
  • Antigens, Protozoan
  • Lipopolysaccharides
  • Receptors, Antigen, T-Cell