Format

Send to

Choose Destination
See comment in PubMed Commons below
Infect Immun. 1997 Sep;65(9):3944-6.

Giardia lamblia infections in B-cell-deficient transgenic mice.

Author information

  • 1Institute of Parasitology, University of Bern, Switzerland.

Abstract

In the present study, we infected B-cell (and antibody-)-deficient transgenic mice with the Giardia lamblia clone GS/M-83-H7. These animals were inhibited in intestinal anti-Giardia immunoglobulin A (IgA) production and could not resolve the parasite infection, and antigenic diversification within the respective parasite populations occurred in an unusually slow manner. These findings indicate an important immunological function of local IgA antibodies which promotes antigenic variation of the parasite and is involved in control of the parasite infection.

PMID:
9284176
PMCID:
PMC175563
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk