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    FEBS Lett. 1997 Jul 14;411(2-3):296-300.

    Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.

    Durkin ME, Loechel F, Mattei MG, Gilpin BJ, Albrechtsen R, Wewer UM.

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    Institute of Molecular Pathology, University of Copenhagen, Denmark.

    Abstract

    To investigate the function of the laminin alpha5-chain, previously identified in mice, cDNA clones encoding the 953-amino-acid carboxy terminal G-domain of the human laminin alpha5-chain were characterized. Northern blot analysis showed that the laminin alpha5-chain is expressed in human placenta, heart, lung, skeletal muscle, kidney, and pancreas. The human laminin alpha5-chain gene (LAMA5) was assigned to chromosome 20q13.2-q13.3 by in situ hybridization, and the mouse gene (Lama5) was mapped by linkage analysis to a syntonic region of distal chromosome 2, close to the locus for the ragged (Ra) mutation.

    PMID:
    9271224
    [PubMed - indexed for MEDLINE]

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