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1: Planta Med. 1997 Aug;63(4):362-3.Links

Inhibition of tyrosine hydroxylase by bulbocapnine.

Zhang YH, Shin JS, Lee SS, Kim SH, Lee MK.

The inhibitory effects of bulbocapnine, an aporphine isoquinoline alkaloid, on bovine adrenal tyrosine hydroxylase (TH) were investigated. Bulbocapnine had an inhibitory effect on the enzyme (43.6% inhibition at concentration of 200 microM). Bulbocapnine exhibited uncompetitive inhibition on bovine adrenal TH with a substrate L-tyrosine. The Ki value was found to be 0.20 mM.

PMID: 9270381 [PubMed - indexed for MEDLINE]