Trends Biochem Sci. 1997 Aug;22(8):299-306.

Caspases: killer proteases.

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Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Inc., Pointe Claire-Dorval, Quebec, Canada.

Abstract

Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key and central role that these enzymes play in a biochemical cell-suicide pathway has been conserved throughout the evolution of multicellular eukaryotes.

PMID:: 9270303; [PubMed - indexed for MEDLINE]

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Review

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Cysteine Endopeptidases

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Mouse Genome Informatics (MGI)

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