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Lancet. 1997 Jun 21;349(9068):1831-3.

Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile?

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  • 1Department of Bacteriology, University College London Medical School, UK.

Abstract

The symptoms of Gulf War syndrome are compatible with the hypothesis that the immune system of affected individuals is biased towards a Th2-cytokine pattern. Factors that could lead to a Th2 shift among Gulf War veterans include exposure to multiple Th2-inducing vaccinations under stressful circumstances and the way in which such vaccinations were administered, which would be expected to maximise Th2 immunogenicity. These factors may have led to a long-term systemic shift towards a Th2-cytokine balance and to mood changes related to the immunoendocrine state. Other vaccines that lead to similar long-term, non-specific shifts in cytokine balance are well-established. If our hypothesis is proven, treatment may be possible with regimens that induce a systemic Th1 bias.

PMID:
9269228
[PubMed - indexed for MEDLINE]
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