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Curr Opin Struct Biol. 1997 Aug;7(4):457-62.

Minimized proteins.

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  • 1Department of Protein Engineering, Genentech Inc., San Francisco, CA 94080, USA. bcc@gene.com

Abstract

The design of bioactive small molecules for interaction at larger protein-protein interfaces remains a challenge. Recent progress towards minimizing proteins into significantly smaller polypeptides has been achieved via both rational design processes and selection from vast combinatorial libraries. Such 'mini-proteins' represent a potential intermediate step toward the development of drugs targeted to protein-protein interfaces.

PMID:
9266165
[PubMed - indexed for MEDLINE]
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