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Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):265-8.

Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development.

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  • 1Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA.


To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration.

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