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Curr Opin Cell Biol. 1997 Aug;9(4):553-9.

The ABCs of ATP-sensitive potassium channels: more pieces of the puzzle.

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  • 1Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.


ATP-sensitive potassium channels, KATP channels are critical for the normal regulation of insulin secretion. The cloning of cDNAs encoding the subunits of these channels shows that they are a novel combination of an ATP-binding protein and a small inward rectifier. Loss of pancreatic beta-cell KATP channels has been shown to cause familial hyperinsulinism.

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